Identification and characterization of MCF01A circular RNAs [RNA-seq]

ABSTRACT: Circular RNAs (circRNAs) are widespread circular forms of non-coding RNAs with largely unknown function. Because stimulation of mammary cells with the epidermal growth factor (EGF) leads to dynamic changes in the abundance of both coding and non-coding RNA molecules, and culminates in the acquisition of a robust migratory phenotype, this cellular model might disclose functions of circRNAs. Here we show that circRNAs of EGF-stimulated mammary cells are stably expressed, while mRNAs and micro-RNAs change within minutes. In general, the circRNAs we detected are relatively long-lived and weakly expressed. Interestingly, they are almost ubiquitously co-expressed with the corresponding linear transcripts, and the respective, shared promoter regions are more active compared to genes producing lin

ORGANISM(S): Homo sapiens

SUBMITTER: Yehoshua Enuka 

PROVIDER: E-GEOD-71195 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress