Prognostic significance of overexpression of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer [152 samples]

ABSTRACT: Background: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Methods: The expression profiles of cancer cells in 152 patients with stage I-III CRC were examined using microarray analysis. High expression in CRC cells, especially in patients with distant recurrences, was a prerequisite to select candidate genes. Thus, we identified eleven candidate genes, and selected Traf2- and Nck-interacting kinase (TNIK), which was known to be associated with progression in CRC through Wnt signaling pathways. We analyzed the protein expression of TNIK using immunohistochemistry (IHC) and investigated the relationship between prot

ORGANISM(S): Homo sapiens

SUBMITTER: Kaoru Mogushi 

PROVIDER: E-GEOD-71222 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress