The Transcriptome Responses of Cardiomyocyte Exposed to Hypothermia

ABSTRACT: Hypothermia affects the body in positive and negative consequences. In cardiac, hypothermia depresses myocardial contraction, slows conduction, and decreases metabolic rate. However, little is known about the molecular mechanism. Here we compare the genes expression of human adult ventricular cardiomyocyte cells (AC16) treated with hypothermia, trying to find changes under different temperatures and then elucidate the candidate genes that may play important roles in the response to hypothermia. A total of 2413 differentially expressed genes (DEGs) were identified by microarray hybridization, which provided abundant data for further analysis. Gene Ontology enrichment analysis revealed that genes related to gene transcriptions, protein and lipid metabolic were significantly enriched. KEGG an

ORGANISM(S): Homo sapiens

SUBMITTER: huishan wang 

PROVIDER: E-GEOD-71361 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress