Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Genome-wide tissue gene expression profiling in Juvenile GÃ¶ttingen Minipigs with customized Agilent microarrays

ABSTRACT: Minipigs have favorable biological characteristics for juvenile toxicity studies to assess efficacy and safety of pediatric drug products. To evaluate at the molecular level the expression of drug targets, drug metabolism pathways or general maturation of organ transcriptomes in minipigs, we used Customized Agilent Micoarrays (Design-ID 050244) for genome-wide gene expression profiling on 9 different tissues from male and female juvenile GÃ¶ttingen minipigs aged 1 week to 24 months. The gene expression results analyzed in this study are further described in Heckel T. et al. (2015) Functional analysis and transcriptional output of the GÃ¶ttingen minipig genome. under submission Data of 72 different tissue samples from 9 tissues (cerebral cortex, hypothalamus, cerebellum, liver, kidney, spleen, bone marrow, testis, ovary) and 4 age groups in female (1 week, 4 weeks, 2 months, 4 months) and 5 age groups in male (1 week, 4 weeks, 2 months, 4 months, 2 years) Goettingen minipigs (Ellegaard) were measured. One tissue was measured in 8 technical replicates. The combination of data of female and male pigs could be seen as a kind of biological replicate for most genes.

ORGANISM(S): Sus scrofa

SUBMITTER: Tobias Heckel

PROVIDER: E-GEOD-71441 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Functional analysis and transcriptional output of the Göttingen minipig genome.

Heckel Tobias T Schmucki Roland R Berrera Marco M Ringshandl Stephan S Badi Laura L Steiner Guido G Ravon Morgane M Küng Erich E Kuhn Bernd B Kratochwil Nicole A NA Schmitt Georg G Kiialainen Anna A Nowaczyk Corinne C Daff Hamina H Khan Azinwi Phina AP Lekolool Isaac I Pelle Roger R Okoth Edward E Bishop Richard R Daubenberger Claudia C Ebeling Martin M Certa Ulrich U

BMC genomics 20151114

<h4>Background</h4>In the past decade the Göttingen minipig has gained increasing recognition as animal model in pharmaceutical and safety research because it recapitulates many aspects of human physiology and metabolism. Genome-based comparison of drug targets together with quantitative tissue expression analysis allows rational prediction of pharmacology and cross-reactivity of human drugs in animal models thereby improving drug attrition which is an important challenge in the process of drug ...[more]

PMID: 26573612

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Dataset Information

Genome-wide tissue gene expression profiling in Juvenile GÃ¶ttingen Minipigs with customized Agilent microarrays

Publications

Functional analysis and transcriptional output of the Göttingen minipig genome.

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