Genome-Wide Expression Profiling of Human Colonic Epithelial Cell Model Co-challenged with Single, Multi-strain Probiotics and Pro-inflammatory Stimulus, poly (I:C)

ABSTRACT: One of the key impacts of probiotic bacteria is the ability to beneficially modulate innate and adaptive immune responses of various cell types of the gut-associated lymphoid tissue. In this study we used an in vitro intestinal epithelial cell model to investigate the impact of three probiotic bacteria Lactobacillus helveticus R0052, Bifidobacterium longum subsp. infantis R0033 and Bifidobacterium bifidum R0071 individually, in combination (R0033, R0052 and R0071) and of a specific surface-layer protein partially purified from L. helveticus R0052 (R0052-SLP) in response to a known dsRNA pro-inflammatory stimulus, poly (I:C). Genome-wide human expression microarray chips were used to evaluate other cellular pathways and gain a deeper insight into global gene and pathway modulation. Here we

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Tompkins 

PROVIDER: E-GEOD-71515 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress