The effects of aging on circadian patterns of gene expression in the human prefrontal cortex

ABSTRACT: With aging, significant changes in circadian rhythms occur, including a shift in phase toward a “morning” chronotype and a loss of rhythmicity in circulating hormones. However, the effects of aging on molecular rhythms in the human brain have remained elusive. Here we employed a previously-described time-of-death analyses to identify transcripts throughout the genome that have a significant circadian rhythm in expression in the human prefrontal cortex (Brodmann’s areas (BA) 11 and 47). Expression levels were determined by microarray analysis in 146 individuals. Rhythmicity in expression was found in ~10% of detected transcripts (p<0.05). Using a meta-analysis across the two brain areas, we identified a core set of 235 genes (q<0.05) with significant circadian rhythms of expression. T

ORGANISM(S): Homo sapiens

SUBMITTER: Etienne Sibille 

PROVIDER: E-GEOD-71620 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress