Effect of Smyd1 conditional knockout on gene expression in skeletal muscle

ABSTRACT: Transcriptome analysis by RNA-seq of tibialis anterior muscle from control and Smyd1 myocyte-specific conditional knockout mice at 6 weeks of age. Smyd1 is a methyltransferase specifically expressed in striated muscle and CD8+ T cells. Smyd1 deficiency resulted in centronuclear myopathy primarily affecting fast-twitch muscle fibers. These results provide insight into how loss of Smyd1 altered transcriptional programs resulting in centronuclear myopathy. 6 animals per group (control and Smyd1 conditional knockout)

ORGANISM(S): Mus musculus

SUBMITTER: M. David Stewart 

PROVIDER: E-GEOD-71679 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress