In Utero Cigarette Smoke Affects Allergic Airway Disease But Does Not Alter the Lung Methylome

ABSTRACT: Introduction: Prenatal and postnatal cigarette smoke exposure enhances the risk of developing asthma. Despite this as well as other smoking related risks, 11% of women still smoke during pregnancy. We hypothesized that cigarette smoke exposure during prenatal development generates long lasting differential methylation altering transcriptional activity that correlates with disease. Methods: In a house dust mite (HDM) model of allergic airway disease, we measured airway hyperresponsiveness (AHR) and airway inflammation between mice exposed prenatally to cigarette smoke (CS) or filtered air (FA). DNA methylation and gene expression were then measured in lung tissue. Results: We demonstrate that HDM-treated CS mice develop a more severe allergic airway disease compared to HDM-treated FA mic

ORGANISM(S): Mus musculus

SUBMITTER: Kenneth Eyring 

PROVIDER: E-GEOD-71718 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress