Molecular hydrogen stimulates the gene expression of a translational coactivator PGC-1alpha to enhance fatty acid metabolism

ABSTRACT: We previously reported that molecular hydrogen (H2) acts as a novel antioxidant to exhibits multiple-functions. Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice, accompanied with the increased gene expression of an energy metabolism stimulatory hepatic hormone, fibroblast growth factor 21 (FGF21); however, the molecular mechanism is unknown particularly on whether this gene regulation is a primary cause or the secondary consequence. Pathway analyses based on comprehensive gene expression revealed the increased expression in various genes involved in fatty acid and steroid metabolisms. As a transcription pathway, the PPARa signaling pathway was identified to up-regulate the genes by 14 day-ingestion

ORGANISM(S): Mus musculus

SUBMITTER: Shigeo Ohta 

PROVIDER: E-GEOD-71738 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress