Muscle mitochondrial stress-induced metabolic adaptations do not require FGF21 action

ABSTRACT: Fibroblast growth factor 21 (FGF21) is a key metabolic regulator which was recently discovered as stress-induced myokine and common denominator of muscle mitochondrial disease. However, its precise function and pathophysiological relevance remains unknown. Here we demonstrate that white adipose tissue (WAT) is the major target of muscle mitochondrial stress-induced FGF21. Strikingly, substantial browning and metabolic remodeling of subcutaneous WAT, together with the reduction of circulating triglycerides and cholesterol are fully FGF21 dependent. Unexpectedly and in contrast to prior expectations, we found a negligible role of FGF21 in muscle stress-related improved glycemic control, obesity resistance and hepatic lipid homeostasis. Furthermore, we show that the protective muscle mitohorm

ORGANISM(S): Mus musculus

SUBMITTER: Evert van Schothorst 

PROVIDER: E-GEOD-71749 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress