A Systems Approach to Understanding Human Rhinovirus and Influenza Virus Infection

ABSTRACT: Human rhinovirus and influenza virus infections of the upper airway lead to colds and the flu and can trigger exacerbations of lower airway diseases including asthma and chronic obstructive pulmonary disease. Despite modest advances in the diagnosis and treatment of infections by these viruses, novel diagnostic and therapeutic targets are still needed to differentiate between the cold and the flu, since the clinical course of influenza can be severe while that of rhinovirus is usually more mild. In our investigation of influenza and rhinovirus infection of human respiratory epithelial cells, we used a systems approach to identify the temporally changing patterns of host gene expression from these viruses. After infection of human bronchial epithelial cells (BEAS-2B) with rhinovirus, influe

ORGANISM(S): Homo sapiens

SUBMITTER: Richard Gelinas 

PROVIDER: E-GEOD-71766 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress