Remodeling of Brown and White Adipose Tissue by NT-PGC-1α-Mediated Gene Regulation

ABSTRACT: The β-adrenergic receptor signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β-AR activation highly induces transcriptional coactivator PGC-1α and its splice variant N-terminal (NT)-PGC-1α, promoting the transcription program of mitochondrial biogenesis and thermogenesis. In the present study, we evaluated the role of NT-PGC-1α in brown adipocyte energy metabolism by genome-wide profiling of NT-PGC-1α-responsive genes. Canonical pathway analysis revealed that a number of genes upregulated by NT-PGC-1α are highly enriched in mitochondrial pathways including fatty acid transport and β-oxidation, TCA cycle and electron transport system, thus reinforcing the crucial role of NT-PGC-1α in the enhancement of mitochondria

ORGANISM(S): Mus musculus

SUBMITTER: Ji Suk Chang 

PROVIDER: E-GEOD-71774 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress