Deletion of DXZ4 on the human inactive X chromosome eliminates superdomains and impairs gene silencing

ABSTRACT: During interphase, the inactive X chromosome (Xi) adopts an unusual 3D configuration known as the Barr body and is largely transcriptionally silent. Despite the importance of X inactivation, little is known about the 3D configuration of Xi and its relationship to gene silencing. We recently showed that in humans, Xi exhibits two distinctive structural features. First, Xi is partitioned into two huge intervals, called superdomains, such that pairs of loci in each superdomain show an enhanced contact frequency with one another. The boundary between the two superdomains lies near DXZ4, a macrosatellite repeat spanning ~300kb, whose Xi allele extensively binds the protein CTCF. Second, Xi exhibits extremely large loops, up to 77Mb long, called superloops. DXZ4 lies at the anchor of several sup

ORGANISM(S): Homo sapiens

SUBMITTER: Miriam Huntley 

PROVIDER: E-GEOD-71831 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress