The DNA methylation landscape of human melanoma (MIRA-Seq)

ABSTRACT: Melanoma genomes are often characterized by large numbers of sunlight-induced mutations. However, epigenetic alterations, in the form of aberrant DNA methylation patterns, are also abundant. Using MIRA-seq, we have carried out a comprehensive characterization of the DNA methylome in a series of metastatic melanoma samples and catalogued the methylation changes relative to normal melanocytes, the presumed cells of origin for these tumors. Individual melanoma tumors contained up to several thousand hypermethylated regions. We discovered 179 tumor-specific methylation peaks that were present in all (27/27) melanomas and may lend themselves as effective disease biomarkers, and 3124 methylation peaks were present in >40% of the tumors. We specifically examined the relationship between presence

ORGANISM(S): Homo sapiens

SUBMITTER: Xiwei Wu 

PROVIDER: E-GEOD-71938 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress