Expression data of SHSY5Y cells after cocaine exposure

ABSTRACT: The aim of the study was to evaluate cocaine-induced changes in gene expression in a dopaminergic model. Cocaine reward and reinforcing effects are mediated mainly by dopaminergic neurotransmission. In this study we aimed at evaluating gene expression changes induced by acute cocaine exposure on SH-SY5Y differentiated cells, which have been widely used as a dopaminergic neuronal model. Expression changes and a concomitant increase in neuronal activity were observed 6 hours after a 5 uM cocaine exposure, whereas no changes in gene expression nor in neuronal activity took place at 1 uM cocaine. A total of 756 differentially expressed genes, mainly related to regulation of transcription and gene expression, cell cycle, adhesion and cell projection, as well as MAPK, CREB, neurotrophin and neur

ORGANISM(S): Homo sapiens

SUBMITTER: Noelia Fernandez-Castillo 

PROVIDER: E-GEOD-71939 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress