Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Long non-coding RNAs in B cells (RNA-Seq)

ABSTRACT: Using RNA sequencing and de novo transcript assembly, we identified 4516 lncRNAs expressed in 8 different stages of B cell development and activation. Chromatin immuno-precipitation sequencing was used to classify a substantial fraction (38%) of these lncRNAs as enhancer-associated or promoter-associated RNAs (eRNAs or pRNAs). A catalogue of lncRNAs expressed in eight murine B cell populations

ORGANISM(S): Mus musculus

SUBMITTER: Jethro Johnson

PROVIDER: E-GEOD-72018 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Long noncoding RNAs in B-cell development and activation.

Brazão Tiago F TF Johnson Jethro S JS Müller Jennifer J Heger Andreas A Ponting Chris P CP Tybulewicz Victor L J VL

Blood 20160705 7

Long noncoding RNAs (lncRNAs) are potentially important regulators of cell differentiation and development, but little is known about their roles in B lymphocytes. Using RNA-seq and de novo transcript assembly, we identified 4516 lncRNAs expressed in 11 stages of B-cell development and activation. Most of these lncRNAs have not been previously detected, even in the closely related T-cell lineage. Comparison with lncRNAs previously described in human B cells identified 185 mouse lncRNAs that have ...[more]

PMID: 27381906

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Dataset Information

Long non-coding RNAs in B cells (RNA-Seq)

Publications

Long noncoding RNAs in B-cell development and activation.

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