Hormetic shifting of redox environment by the ROS-producing polyphenol resveratrol protects cells from oxidative stress

ABSTRACT: Resveratrol is a natural product that has gained tremendous interest due to multiple reported health-beneficial effects. However, the underlying mechanisms of action of this compound remained largely controversial. Here, we demonstrate that major biological effects of resveratrol might be attributed to its bicarbonate-induced production of phenolic radicals and reactive oxygen species (ROS) such as superoxide and hydrogen peroxide under physiologically relevant conditions. These products derived from low hormetic micromolar concentrations of resveratrol led to gene expression reprogramming, which was mainly controlled by the redox-sensitive transcription factor nuclear factor (erythroid-derived 2) like 2 (Nrf2), whereas too high concentrations of resveratrol became detrimental for cells. G

ORGANISM(S): Homo sapiens

SUBMITTER: Annabell Plauth 

PROVIDER: E-GEOD-72119 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress