Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jinsheng Yu
PROVIDER: E-GEOD-72139 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature 20160601 7608
Over 50% of patients who survive neuroinvasive infection with West Nile virus (WNV) exhibit chronic cognitive sequelae. Although thousands of cases of WNV-mediated memory dysfunction accrue annually, the mechanisms responsible for these impairments are unknown. The classical complement cascade, a key component of innate immune pathogen defence, mediates synaptic pruning by microglia during early postnatal development. Here we show that viral infection of adult hippocampal neurons induces complem ...[more]