Transcription profiling of human lung carcinome calls treated WITH Farnesol reveals Farnesol-induced apoptosis IS coupled TO THE endoplasmic reticulum (ER) stress response

ABSTRACT: Farnesol (FOH) and other isoprenoid alcohols induce apoptosis in various carcinoma cells and inhibit tumorigenesis in several in vivo models. However, the mechanisms by which these isoprenoids mediate their effects are not yet fully understood. In this study, we show that FOH is effective inducer of apoptosis in several lung carcinoma cells, including H460 cells. This induction is associated with activation of caspase-3, -9, and -12, and cleavage of PARP. To obtain insight into the mechanism involved in FOH-induced apoptosis, we compared the gene expression profiles of FOH-treated and control H460 cells using microarray analysis. This analysis revealed that many of the genes implicated in endoplasmic reticulum (ER) stress, including ATF3, CHOP/GADD153, HERPUD1, BIP (GRP78), XBP1, PDIA4, an

ORGANISM(S): Mus musculus

SUBMITTER: NIEHS Microarray Group 

PROVIDER: E-GEOD-7215 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress