Embryonic atrazine exposure elicits neuroendocrine dysfunction in adult male zebrafish (brain)

ABSTRACT: The developmental origins of health and adult disease (DOHaD) hypothesis states that exposure to various environmental stressors early in life can elicit changes to the genome and epigenome thereby resulting in an increased susceptibility of a disease state during adulthood. Atrazine, a common herbicide used throughout the Midwestern United States for control of weeds on various crops frequently contaminates potable water supplies and is a suspected endocrine disrupting chemical. Studies suggest atrazine elicits reproductive dysfunction through the hypothalamus-pituitary-gonadal (HPG) axis. In previous studies, zebrafish were exposed to 0.3, 3, or 30 parts per billion (ppb; ug/L) atrazine through embryogenesis, rinsed, and allowed to mature to adulthood. A decrease in spawning was observed

ORGANISM(S): Danio rerio

SUBMITTER: Jennifer Freeman 

PROVIDER: E-GEOD-72243 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress