Transcription profiling of mouse cumulus cells from Bmp15-/- and Bmp15-/-Gdf9+/--DM animals

ABSTRACT: Mouse oocytes control cumulus cell metabolic processes that are deficient in the oocytes themselves and this delegation is necessary for oocyte development. Oocyte-derived bone morphogenetic factor 15 (BMP15) and growth differentiation factor 9 (GDF9) appear to be key regulators of follicular development. The effect of these factors on cumulus cell function before the preovulatory surge of luteinizing hormone (LH) was assessed by analysis of the transcriptomes of cumulus cells from wildtype (WT), Bmp15-/-, and Bmp15-/- Gdf9+/- double mutant (DM) mice using microarray analysis. The biological themes associated with the most highly-affected transcripts were identified using bioinformatic approaches, IPA and GenMAPP/MAPPFinder. There were 5,332, 7,640, and 2,651 transcripts identified to be

ORGANISM(S): Mus musculus

SUBMITTER: You-Qiang Su 

PROVIDER: E-GEOD-7225 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress