Intra-subject correlation of brain and blood gene expression in a mouse model of depression

ABSTRACT: Gene expression profiling of blood cells in patients with major depressive disorder (MDD) has been used to identify potential biomarkers and to address the pathophysiology of MDD. However, whether alteration in gene expression in blood cells are reflected in the brain of the same individual is unclear. Here, we used an animal model of depression to investigate intra-subject correlation of gene expression patterns between the whole blood (WB) and the medial prefrontal cortex (mPFC). Ovariectomized mice exposed to the chronic ultra-mild stress were used as an animal model of depression. The major findings of the current genome-wide microarray analysis are that 1) the expression levels of 467 genes that were expressed in both tissues correlated positively between the two tissues, 2) alteratio

ORGANISM(S): Mus musculus

SUBMITTER: Shigeo Miyata 

PROVIDER: E-GEOD-72262 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress