Genome-wide analyses for the WOPR regulator osaA and the velvet regulator veA

ABSTRACT: Orchestration of cellular growth and development occurs during the life cycle of Aspergillus nidulans. A multi-copy genetic screen intended to unveil novel regulators of development identified the AN6578 locus predicted to encode a protein with the WOPR domain, which is a broadly present fungi-specific DNA-binding motif. Multi-copy of AN6578 disrupted the normal life cycle of the fungus leading to enhanced proliferation of vegetative cells, whereas the deletion resulted in hyper-active sexual fruiting with reduced asexual development (conidiation), thus named as osaA (Orchestrator of Sex and Asex). Further genetic studies indicate that OsaA balances development mainly by repressing sexual development downstream of the velvet regulator VeA. The absence of osaA is sufficient to suppress the

ORGANISM(S): Aspergillus nidulans

SUBMITTER: Fahad Alkhayyat 

PROVIDER: E-GEOD-72316 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress