Characterization of the ToxR Regulon Vibrio cholerae El Tor

ABSTRACT: The transcriptional factor ToxR initiates a virulence regulatory cascade required for V. cholerae to express critical host colonization factors and cause disease. Genome-wide expression studies suggest that ToxR regulates many genes important for V. cholerae pathogenesis, yet our knowledge of the direct regulon controlled by ToxR is limited to just four genes. Here, we determine ToxR’s genome-wide DNA-binding profile and show that ToxR is a global regulator of both progenitor genome-encoded genes and horizontally acquired islands encoding the majority of V. cholerae’s major virulence factors. Our results suggest that ToxR has gained regulatory control over important acquired elements that not only drive V. cholerae pathogenesis but that also define the major transitions of V. cholerae

ORGANISM(S): Vibrio cholerae O1 str. C6706

SUBMITTER: Bryan Davies 

PROVIDER: E-GEOD-72473 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress