Transcription profiling of rat kidney in diabete mellitus during puberty

ABSTRACT: Puberty unmasks or accelerates nephropathies, including the nephropathy of diabetes mellitus (DM). A number of cellular systems implicated in the kidney disease of DM interweave, forming an interdependent functional web. We performed focused microarray analysis to test the hypothesis that one or more genes in the transforming growth factor beta (TGF-β) signaling system would be differentially regulated in male rats depending on the age of onset of DM. Experiment Overall Design: Male rat littermates began the 6-week-protocol at 4 or 14 weeks of age with injection of streptozocin, 65 mg/kg iv, or equal volume of vehicle. 3 days later insulin palmitate or palmitate vehicle pellets were implanted once hyperglycemia was confirmed. Rats received ad lib food and water for 6 weeks and maintained

ORGANISM(S): Rattus norvegicus

SUBMITTER: Pascale Hammond Lane 

PROVIDER: E-GEOD-7253 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress