Transcription profiling of rat kidney in diabete mellitus during puberty
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Pascale Hammond Lane
PROVIDER: E-GEOD-7253 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Prepubertal onset of diabetes prevents expression of renal cortical connective tissue growth factor.
Langer William J WJ Devish Kay K Carmines Pamela K PK Lane Pascale H PH
Pediatric nephrology (Berlin, Germany) 20071121 2
Puberty unmasks or accelerates the nephropathy of diabetes mellitus (DM). We performed focused microarray analysis to test the hypothesis that one or more genes in the transforming growth factor beta (TGF-beta) signaling system would be differentially regulated in male rats depending on their age at onset of DM. Littermates were started on the 6-week protocol at 4 weeks or 14 weeks of age. Renal cortical RNA was isolated and analyzed using gene chips with more than 30,000 transcripts. Age-specif ...[more]
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