Reconstructing gene regulatory networks of tumorigenesis [ChIP-Seq]

ABSTRACT: The mechanistic links between transcription factors and the epigenetic landscape, which coordinate the deregulation of gene networks during cell transformation are largely unknown. We used an isogenic model of stepwise tumorigenic transformation of human primary cells to monitor the progressive deregulation of gene networks upon immortalization and oncogene-induced transformation. By combining transcriptome and epigenome data for each step during transformation and by integrating transcription factor (TF) - target gene associations, we identified 142 TFs and 24 chromatin remodelers/modifiers (CRMs), which are preferentially associated with specific co-expression paths that originate from deregulated gene programming during tumorigenesis. These TFs are involved in the regulation of divers p

ORGANISM(S): Homo sapiens

SUBMITTER: Valeriya Malysheva 

PROVIDER: E-GEOD-72532 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress