Maternal Weight Phenotype as a Predictor of Methylation of Obesity-Related CpG Sites in Saliva Samples from Latino Children

ABSTRACT: Epigenetics presents a dynamic approach to assess complex individual variation in obesity susceptibility. However, few studies have examined epigenetic patterns in preschool-age children, despite the relevance of this developmental stage to trajectories of weight gain, because of difficulties obtaining blood tissue samples. This proof of principle study examined DNA methylation in 92 saliva samples, comparing Latino preschool children of normal weight mothers (Body Mass Index [BMI] <27 kg/m2 and WC <90 cm) to children of obese mothers (BMI >30 kg/m2 and WC >100 cm). We hypothesized that salivary DNA methylation patterns in Latino preschool age children born of normal weight vs obese weight mothers would be: 1) associated with maternal BMI phenotype in continuous linear regression analysis;

ORGANISM(S): Homo sapiens

SUBMITTER: Yan Guo 

PROVIDER: E-GEOD-72556 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress