Transcription profiling of bronchoalveolar lavage cells from AJ mice treated with urethane vs. controls

ABSTRACT: AJ mouse is susceptible to lung carcinogenesis from urethane treatment and is a good model for human adenocarcinoma. We completed a study using microarray analysis of bronchoalveolar lavage cells from control or urethane treated mice. A unique macrophage expression signature in the lung tumor microenvironment was able to correctly classify the lavage samples. Experiment Overall Design: RNA from bronchoalveolar lavage cells of age matched untreated AJ mice controls (C) or from urethane treated (T) AJ mice was prepared. Datasets were accurately classified using a unique macrophage gene expression signature derived from the tumor microenvironment.

ORGANISM(S): Mus musculus

SUBMITTER: Robert Stearman 

PROVIDER: E-GEOD-7258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress