Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of bronchoalveolar lavage cells from AJ mice treated with urethane vs. controls

ABSTRACT: AJ mouse is susceptible to lung carcinogenesis from urethane treatment and is a good model for human adenocarcinoma. We completed a study using microarray analysis of bronchoalveolar lavage cells from control or urethane treated mice. A unique macrophage expression signature in the lung tumor microenvironment was able to correctly classify the lavage samples. Experiment Overall Design: RNA from bronchoalveolar lavage cells of age matched untreated AJ mice controls (C) or from urethane treated (T) AJ mice was prepared. Datasets were accurately classified using a unique macrophage gene expression signature derived from the tumor microenvironment.

ORGANISM(S): Mus musculus

SUBMITTER: Robert Stearman 

PROVIDER: E-GEOD-7258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A macrophage gene expression signature defines a field effect in the lung tumor microenvironment.

Stearman Robert S RS   Dwyer-Nield Lori L   Grady Michael C MC   Malkinson Alvin M AM   Geraci Mark W MW  

Cancer research 20080101 1

One area of intensive investigation is to understand complex cellular and signaling interactions in the tumor microenvironment. Using a novel, although straightforward, microarray approach, we defined a gene expression signature from the lung tumor microenvironment in the murine A/J-urethane model of human lung adenocarcinoma. The tumor microenvironment is reflected by the composition of the cell types present and alterations in mRNA levels, resulting in a "Field Effect" around the tumor. The ge  ...[more]

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