Expression profiling of fibroblasts treated with miR-211 and miR-320c

ABSTRACT: mRNA profiles generated from primary fibroblast upon treatment with miR-211, miR-302 or melanoma melanosomes. Abstract: Melanoma originates in the epidermis and enters the metastatic and lethal phase upon invasion into the dermis. However, the interactions between melanoma cells and the dermis prior to this invasion have been poorly studied. Here we uncover that melanoma cells directly affect the formation of the dermal tumor niche by microRNA (miRNA) trafficking prior to invading the dermis. Melanocytes, the cells of melanoma origin, are specialized in trafficking of pigment vesicles, termed melanosomes and, interestingly, melanoma cells retain this trafficking ability. In melanoma in-situ specimens, we found melanosome markers in distal fibroblasts prior to the invasion of melanoma cells

ORGANISM(S): Homo sapiens

SUBMITTER: Carmit Levy 

PROVIDER: E-GEOD-72619 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress