5-Hydroxymenthylation-associated Epigenetic Modifiers in Alzheimer's disease

ABSTRACT: Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive deterioration of cognitive function. Evidence suggests a role for epigenetic regulation, in particular the cytosine modifications 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC,) in AD. 5hmC is highly enriched in the nervous system and displays neurodevelopment and age-related changes. To determine the role of 5hmC in AD, we performed genome-wide analyses of 5hmC in DNA from prefrontal cortex of post-mortem AD as well as RNA-Seq to correlate changes in methylation status with transcriptional changes. We also utilized the existing AD fly model to further test the functional significance of these epigenetically altered loci. We identified 325 genes containing differentially hydroxymethylat

ORGANISM(S): Homo sapiens

SUBMITTER: Peng Jin 

PROVIDER: E-GEOD-72782 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress