Regulation of the biofilm-specific genes circuitry in Candida albicans by a novel histone H3 variant

ABSTRACT: To understand the biological relevance of the role played by the HHT1 histone H3 variant in C. albicans, we performed a transcriptome analysis of the mutant by global gene expression array analysis. We analyzed gene expression profile of the mutant in strains LR107 and LR108 (hht1∆/hht1∆) and the parent wild type (SC5314) strain grown in YPD liquid medium at 30°C. In the microarray analysis, a total of 1222 genes were found to be expressed significantly different (fold change < 1.5 at p-value < 0.05) between wild type and two hht1 null mutants. Out of the 1222 differentially expressed genes, 670 genes were up-regulated whereas 552 genes were down-regulated. Gene ontology (GO) analysis of up-regulated and down-regulated genes suggests that biofilm, Hap43, transcription, filamentation,

ORGANISM(S): Candida albicans

SUBMITTER: Genotypic technology 

PROVIDER: E-GEOD-72824 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress