Paracrine stimulation effect of autologous salispheres on mouse salivary gland

ABSTRACT: Human salispheres, a culture of stem/progenitor cells, represent a potential therapy for radiation induced hyposalivation. Radiation-induced hyposalivation dramatically reduces quality of life of patients. We have demonstrated the potential of human salispheres to engraft and differentiate when transplanted into a mouse model of hyposalivation, in the manuscript associated with these data. We also demonstrate the functional recovery of irradiated salivary glands (SGs) following human salisphere transplantation, by the measurement of saliva production. We previously employed Illumina microarrays to determine if transplanted human salisphere cells exert a paracrine stimulatory effect on recipient mouse SGs. Results of this array unveiled a large cohort of immuneresponse genes unregulated fo

ORGANISM(S): Homo sapiens

SUBMITTER: Sarah Pringle 

PROVIDER: E-GEOD-72870 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress