Molecular evolution of Acinetobacter baumannii strains (belonging to ST-2 clone) in a decade: Role of phages

ABSTRACT: Phages have emerged as prime suspects in the adaptation of pathogens to new hosts and the emergence of new pathogens or epidemic clones. Here we describe the genomic features of “swarms” of three related prophages (Ab105-1ϕ, Ab105-2ϕ and Ab105-3ϕ) present in the ST-2 epidemic clone of Acinetobacter baumannii clinical strain Ab105 GEIH-2010 and not present in genetically related Ab155 GEIH-2000 strain isolated 10 years before. The “Quasicore genome” of Ab105-1ϕ, Ab105-2ϕ and Ab105-3ϕ prophages revealed genes that promote bacterial-host fitness. The results of microarray analysis under stress conditions, SOS response and Quorum Sensing (QS) activation revealed 42% and 21% of genes expressed by Ab105-2ϕ and Ab105-3ϕ prophages (which produce bacterial lysis) in the first case and underexpressi

ORGANISM(S): Acinetobacter baumannii

SUBMITTER: Maria Tomas-Carmona 

PROVIDER: E-GEOD-72885 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress