HDAC4 gene therapy

ABSTRACT: Black six animals received either an Adeno associated virus leading to overexpression of Luciferase or Histone deacetyase 4 aminoacids 1-201. After 3 weeks of expression, animals got transaortic banding (TAC) to induce pathological cardiac remodeling. We compared both groups to Back six animals with sham surgery and overexpression of Luziferase. 3 male animals per group (5 replicates) at an age of 8 weeks were treated with an adenoassociated virus (AAV) containing a coding sequence for Luziferase or Histone Deacetylase 4 (aminoacids 1-201) und der the control of the MLC-promoter. Both groups were then exposed to transaortic constriction. As a control served AAV treated animals with overepression of luziferase and sham.

ORGANISM(S): Mus musculus

SUBMITTER: Carsten Sticht 

PROVIDER: E-GEOD-72904 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress