MicroRNA profiles in Parkinsonâ??s disease prefrontal cortex

ABSTRACT: Objective. The goal of this study was to examine the microRNA (miRNA) profile of Parkinsonâ??s disease (PD) frontal cortex as compared to normal control brain, allowing for the identification of PD specific signatures as well as the study of disease-related phenotypes, such as onset age or dementia Methods. Small RNA sequence analysis was performed from prefrontal cortex for 29 PD samples and 33 control samples. After sample QC, normalization and batch correction, linear regression was used to identify miRNAs altered in PD, and a PD classifier was developed using weighted voting class prediction. The relationship of miRNA levels to onset age and PD with dementia (PDD) was also characterized in case-only analyses. Results. 125 miRNAs were differentially expressed in PD at a genome-wide leve

ORGANISM(S): Homo sapiens

SUBMITTER: Richard Myers 

PROVIDER: E-GEOD-72962 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress