A novel combination of serum microRNAs for detecting breast cancer in the early stage

ABSTRACT: MicroRNAs (miRNAs), which are stably present in serum, have been reported to be potentially useful for detecting cancer. In the present study, we examined the expression profiles of serum miRNAs in large cohorts to identify the miRNAs that can be used to detect breast cancer in the early stage. We comprehensively evaluated serum miRNA expression profiles using highly sensitive microarray analysis. A total of 1,280 serum samples of breast cancer patients stored in the National Cancer Center Biobank were used. Additionally, 2,836 serum samples were obtained from non-cancer controls and 514 from patients with other types of cancers or benign diseases. The samples were divided to a training cohort including non-cancer controls, other cancers and breast cancer and a test cohort including non-ca

ORGANISM(S): Homo sapiens

SUBMITTER: Satoko Takizawa 

PROVIDER: E-GEOD-73002 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress