Insulin resistance in high fat diet mouse

ABSTRACT: Recent discovery reveals HFD insult can cause insulin resistance very rapidly, but the underlying mechanism is still not well understood. We performed a short term experiment in a Diet Induced Insulin resistance mouse model. Objective: Insulin resistance (IR) is one of the earliest predictors of type 2 diabetes. However, diagnosis of IR is limited. High fat fed mouse models provide key insights into IR. We hypothesized that early features of IR are associated with persistent changes in gene expression (GE) and endeavoured to (a) develop novel methods for improving signal:noise in analysis of human GE using mouse models; (b) identify a GE motif that accurately diagnoses IR in humans; and (c) identify novel biology associated with IR in humans. Methods: We integrated human muscle GE data wit

ORGANISM(S): Mus musculus

SUBMITTER: Rima Chaudhuri 

PROVIDER: E-GEOD-73036 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress