Gene expression data from CNS-PNETs and various other brain tumor samples

ABSTRACT: Primitive neuroectodermal tumors of the central nervous system (CNS PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children. Using DNA methylation and gene expression profiling we have demonstrated that a significant proportion of institutionally diagnosed CNS PNETs display molecular profiles indistinguishable from those of various other well defined CNS tumor entities, facilitating diagnosis and appropiate therapy for children with these tumors. From the remaining fraction of CNS PNETs, we have identified four distinct new CNS tumor entities extending to other neuroepithelial tumors, each associated with a recurrent genetic alteration and particular histopathological and clinical features. These molecular entities, designated “CNS N

ORGANISM(S): Homo sapiens

SUBMITTER: Marcel Kool 

PROVIDER: E-GEOD-73038 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress