Cis-encoded sRNAs repress expression of polysaccharide utilization loci in Bacteroides fragilis 638R

ABSTRACT: The phylum Bacteroidetes is a major component of the human gut microbiota which has a broad impact on the development and physiology of its host, and a potential role in a wide range of disease syndromes1-3. The predominance of Bacteroidetes and the genus Bacteroides in the distal gut is due in large part to the expansion of paralogous gene clusters, termed Polysaccharide Utilization Loci (PULs), dedicated to the uptake and catabolism of host derived and dietary polysaccharides4,5. It is generally thought that the diversity of PULs is key to Bacteroides successful competition for nutrients in the gut environment6. The nutritive value of the available polysaccharides varies greatly and thus their utilization is hierarchical and strictly controlled. A typical PUL includes regulatory genes t

ORGANISM(S): Bacteroides fragilis 638R

SUBMITTER: Charles Smith 

PROVIDER: E-GEOD-73107 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress