Single-cell transcriptome profiling for metastatic renal cell carcinoma patient-derived cells [aCGH]

ABSTRACT: Clear cell renal cell carcinoma (ccRCC) initiated from the renal epithelium is the most prevalent histological type of adult kidney cancers. Dissecting intratumoral heterogeneity (ITH) of ccRCC has leveraged to extend our knowledge on how primary tumors harboring driver mutations evolve and spread to other sites. The cellular fractions within and across the primary (pRCC) and metastatic RCC (mRCC) are heterogeneous in both their genetic and biological features determining the variability in clinical aggressiveness and sensitivity to the therapy. To achieve sustainable therapeutic benefit with targeted agents in mRCC, the effective target should focus on signaling pathways that are related to driver mutations occurred early in the clonal evolution of the disease and thus should be common to

ORGANISM(S): Homo sapiens

SUBMITTER: Kyu-Tae Kim 

PROVIDER: E-GEOD-73119 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress