Decorin and EphA2 mediate Carcinoembryonic Antigen Cell Adhesion Molecule 1-L inhibition of colorectal cancer metastasis

ABSTRACT: Objective We have previously shown that expression of the CEACAM1 long isoform (CC1-L) in metastatic colorectal cancer (CRC) cells results in significant inhibition of liver metastasis via Chemokine (C-C motif) Ligand 2 (CCL2) and Signal Transducer and Activator of Transcription 3 (STAT3) signaling. Yet, despite recent advances in identifying molecules involved in the CC1-L inhibition of metastasis, much remains to be elucidated regarding the molecular mechanisms orchestrating this pathway. Design We performed an untargeted transcript profiling and a phosphokinase screen between CC1-L-expressing and non-expressing (CT) CRC cells. Identified targets were validated in vitro and in vivo for their involvement in signaling and invasion or metastasis. We validated our conclusions in CRC pa

ORGANISM(S): Mus musculus

SUBMITTER: Gregory VOISIN 

PROVIDER: E-GEOD-73208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress