Promoter H3K4 methylation dynamically reinforces activation-induced pathways in human CD4 T cells

ABSTRACT: The epigenetic determinants driving the rapid responses of memory CD4 T cells to antigen are currently an area of active research. While much has been done to characterize various Th subsets and their associated genome-wide epigenetic patterns, the dynamics of histone modifications during CD4 T cell activation and the differential kinetics of these epigenetic marks between naïve and memory T cells have not been evaluated. In this study we have detailed the dynamics of genome-wide promoter H3K4me2 and H3K4me3 over a time course during activation of human naïve and memory CD4 T cells. Our results demonstrate that changes to H3K4 methylation predominantly occur relatively late after activation (120 hours) and reinforce activation-induced upregulation of gene expression affecting multiple

ORGANISM(S): Homo sapiens

SUBMITTER: Ryan Thompson 

PROVIDER: E-GEOD-73212 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress