Transcription profiling of rat hippocampus response to ketone bodies

ABSTRACT: Diets characterized by increased blood levels of ketone bodies can protect the brain against a variety of acute and chronic neurological diseases. Moreover, ketone bodies are neuroprotective in many in vitro models of neurological injury. The underlying mechanisms remain unknown however. Recently, we have shown that ketone bodies do not only decrease neuronal injury and death but also protect long-term potentiation in acute hippocampal slices exposed to oxidative stress in the form of exogenous hydrogen peroxide. Elucidating the mechanisms behind the effects of ketone bodies on neuronal survival and function will undoubtedly lead to the development of novel neuroprotective treatments. Our aim is to determine acute changes in gene expression of CA1 pyramidal neurons exposed to various durat

ORGANISM(S): Rattus norvegicus

SUBMITTER: Elizabeth Salomon 

PROVIDER: E-GEOD-7323 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress