Gene expression profiling of mice given orally a supplement with special amino acid composition of Vespa larval saliva origin (DW vs VAAM)

ABSTRACT: VAAM stands for an amino acid mixture simulating the composition of Vespa, a hornet larval saliva. We conducted a comparative study on metabolism-regulatory roles of VAAM, casein-simulating amino acid mixture (CAAM), and pure water on murine hepatic and adipose tissue transcriptomes. Mice were orally fed VAAM solution ( 0.675 g/ kg BW = 2% of food-derived amino acids = 0.38% of total food energy/ day), CAAM solution ( 0.675 g / kg BW/ day) or water under ad libitum for five days. Hepatic transcriptome comparison of VAAM, CAAM and water-treated groups revealed a VAAM-specific regulation of the metabolic pathway, i.e., the down-regulation of glycolysis and fatty acid oxidation, and up-regulation of poly unsaturated fatty acid synthesis and glycogenic amino acids utilization in TCA cycle. Sim

ORGANISM(S): Mus musculus

SUBMITTER: Fumika SHINOZAKI 

PROVIDER: E-GEOD-73264 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress