Identification of drugs that enhance skin repair using dermal stem cell-based screens [Rat]

ABSTRACT: Here, we asked whether we could identify pharmacological agents that enhance endogenous stem cell function to promote skin repair, focusing on SKPs (skin-derived precursors) a dermal precursor cell population. Libraries of compounds already used in humans were screened for their ability to enhance the self-renewal of human and rodent SKPs. We identified and validated 5 such compounds, and showed that two of them, alprostadil and trimebutine maleate, enhanced the repair of full thickness skin wounds in middle-aged mice. Moreover, SKPs isolated from drug-treated skin displayed long-term increases in self-renewal when cultured in basal growth medium without drugs. Both alprostadil and trimebutine maleate likely mediated increases in SKPs self-renewal by moderate hyperactivation of the MEK-ERK

ORGANISM(S): Rattus norvegicus

SUBMITTER: Freda Miller 

PROVIDER: E-GEOD-73328 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress