Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Discovery of progenitor signatures by time series synexpression analysis during Drosophila cell immortalization [RNA-Seq]

ABSTRACT: To characterize the sequence of events associated with RasV12 immortalization of Drosophila embryonic cells, we generated transcriptional time series during cell line establishment, from primary cultures until passage (P) 19. We generated three transcriptional time series from three cell lines (R1, R4 and R5) by sampling the cultures at successive stages, early (P2-4), intermediate (P4-11), and late (P16-19), characterized by different passage times. Time points for the R1 time-series were: P2, P3, P4, P5, P7, P8, P10, P11, P16, P17 and P19; for the R4 time-series: P2, P3, P4, P5, P6, P7, P9, P11, P12, P16, P17 and P19; and for the R5 time-series: P2, P3, P4, P6, P7, P8, P16, P17 and P19

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Mary-Lee Dequeant

PROVIDER: E-GEOD-73353 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Project description:SBML model exported from PottersWheel on 2007-09-19 15:35:47. The values for parameters and the inital concentrations of this model where directly provided by the main author: Parameter values parameter value unit p1 0.0025 1/min p2 0.0784 1/min p3 0.0013 1/min p4 0.0827 1/min p5 0.0091 1/min p6 0.000064 1/(nmole*min) p7 0.0397 1/min p8 1000 nmole p9 0.0098 1/(nmole*min) p10 1.6 1/min p11 1000 nmole p12 0.0003 ml/min The basal chamber volume was taken as 1 ml, the apical as 1.5. As starting values x1 was set to 88 nmole, all other species to 0. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

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Discovery of progenitor signatures by time series synexpression analysis during Drosophila cell immortalization [RNA-Seq]

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