Targeted deletion of miR-132/212 impairs memory and alters the hippocampal transcriptome

ABSTRACT: miR-132 and miR-212 are structurally-related microRNAs that have been found to exert powerful modulatory effects within the central nervous system (CNS). Notably, these microRNAs are tandomly processed from the same non-coding transcript, and share a common seed sequence: thus it has been difficult to assess the distinct contribution of each microRNA to gene expression within the CNS. Here, we employed a combination of conditional knockout and transgenic mouse models to examine the contribution of the miR-132/212 gene locus to learning and memory, and then to assess the distinct effects that each microRNA has on hippocampal gene expression. Using a conditional deletion approach, we show that miR-132/212 double knockout mice exhibit significant cognitive deficits in spatial memory, recognit

ORGANISM(S): Mus musculus

SUBMITTER: Katelin Hansen 

PROVIDER: E-GEOD-73413 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress