Genome-wide mapping of Mef2c-bound sites in early B-cell progenitors

ABSTRACT: The sequential activation of distinct developmental gene networks governs the ultimate identity of a cell, but the mechanisms by which downstream programs are activated are incompletely understood. The preB-cell receptor (preBCR) is an important checkpoint of B-cell development and essential for a preB-cell to traverse into an immature B-cell. Here, we show that activation of Mef2 transcription factors by preBCR is necessary for initiating the subsequent genetic network. We demonstrate that B-cell development is blocked at the preB-cell stage in mice deficient for Mef2c and Mef2d transcription factors and that preBCR signaling enhances the transcriptional activity of Mef2c/d through phosphorylation by the ERK5 mitogen activating kinase. This activation is instrumental in inducing Krüppel-

ORGANISM(S): Mus musculus

SUBMITTER: Julia Herglotz 

PROVIDER: E-GEOD-73453 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress