The bromodomain protein BRD4 regulates splicing during heat shock

ABSTRACT: During heat stress cyto-protective genes including heat shock proteins are transcriptionally up-regulated and post-transcriptional splicing is inhibited. In contrast, co-transcriptional mRNA-splicing is maintained. These factors closely resemble the proteotoxic stress response during tumor development. The bromodomain protein BRD4 has been identified as an integral member of the oxidative stress as well as of the inflammatory response. Furthermore, there is evidence for BRD4's role in splicing regulation; Using RNA-Seq analyses we indeed found a significant increase in splicing inhibition, in particular intron retentions, during heat treatment in BRD4-deficient cells, but not under normal conditions. Subsequent experiments revealed that heat stress leads to the recruitment of BRD4 to nucle

ORGANISM(S): Homo sapiens

SUBMITTER: Michal Schweiger 

PROVIDER: E-GEOD-73471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress