Unique inflammatory transcriptome profiles at the maternal fetal interface and onset of human preterm and term birth

ABSTRACT: Preterm birth is a main determinant of neonatal mortality and morbidity and a major contributor to the overall mortality and burden of disease. However, precise phenotyping of the preterm birth is hampered by the imprecise definition of the clinical phenotype and complexity of the molecular phenotype due to multiple pregnancy tissue types and molecular processes that may contribute to the preterm birth. The studyâ??s aim was to comprehensively evaluate the mRNA transcriptome that characterizes preterm and term labor using precisely phenotyped samples. Expression profiles of 73 genes and non-coding RNA sequences uniquely identified the four groups of patients: delivering preterm with (PL) and without labor (PNL), term with (TL) and without labor (TNL). The largest differences in gene expre

ORGANISM(S): Homo sapiens

SUBMITTER: Don Baldwin 

PROVIDER: E-GEOD-73685 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress